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Functional analogs of bleomycin: sequence-specific DNA cleavage with porphyrin (Fe) intercalators.

作者信息

Hashimoto Y, Iijima H, Shudo K

出版信息

Gan. 1984 Jul;75(7):567-70.

PMID:6205929
Abstract

Synthetic porphyrin (Fe) intercalators cleave DNA at guanine-cytosine and guanine-thymine sequences. The specificity for cleavage of base sequences of DNA is quite similar to that of bleomycin.

摘要

相似文献

1
Functional analogs of bleomycin: sequence-specific DNA cleavage with porphyrin (Fe) intercalators.
Gan. 1984 Jul;75(7):567-70.
2
2-Aminodipyrido[1,2-a:3',2'-d]imidazole-porphyrin(Fe) derivatives as sequence specific DNA cleaving reagents.
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3
Two bases are eliminated from DNA by treatment with bleomycin or with hemin-intercalators.通过用博来霉素或血红素嵌入剂处理，从DNA中去除两个碱基。
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The interaction of unfused polyaromatic heterocycles with DNA: intercalation, groove-binding and bleomycin amplification.未融合多芳杂环与DNA的相互作用：嵌入、沟槽结合及博来霉素扩增
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Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models.一系列吖啶和吖啶唑-铁卟啉作为功能性博来霉素模型的脱氧核糖核酸切割特异性
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8
DNA structure influences sequence specific cleavage by bleomycin.DNA结构影响博来霉素的序列特异性切割。
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Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin.通过肽衍生的天然产物纺锤菌素、放线菌素和博来霉素对DNA结合进行荧光嵌入剂置换分析。
Bioorg Med Chem. 2006 May 15;14(10):3481-90. doi: 10.1016/j.bmc.2006.01.006. Epub 2006 Jan 24.
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引用本文的文献

1
Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins.通过与卟啉共价连接的互补寡核苷酸对核酸进行序列靶向化学修饰。
Nucleic Acids Res. 1987 Nov 11;15(21):8643-59. doi: 10.1093/nar/15.21.8643.