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Globin synthetic ratios in homozygous beta-thalassemia patients from Lebanon.

作者信息

Chehab F F, Khouri F P, Deeb S S

出版信息

Hemoglobin. 1984;8(2):151-62. doi: 10.3109/03630268408991708.

DOI:10.3109/03630268408991708
PMID:6206028
Abstract

We have studied patients with beta-thalassemia from a Lebanese population having a high rate of consanguineous matings. This population exhibits both elevated and normal levels of Hb A2 associated with high levels of Hb F in homozygotes. The clinical course of the anemia suggests that this population consists of the severe Mediterranean type. Twenty-three unrelated homozygous beta-thalassemia patients investigated for globin synthetic ratios, consisted of 18 beta+ and 5 beta 0 with a non-alpha/alpha range of 0.158-0.465 and 0.25-0.41, respectively. The percentage of G gamma chains in Hb F was determined for 21 of these patients and a mean value of 59% G gamma chain content was found.

摘要

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