Globin synthetic ratios in homozygous beta-thalassemia patients from Lebanon.

We have studied patients with beta-thalassemia from a Lebanese population having a high rate of consanguineous matings. This population exhibits both elevated and normal levels of Hb A2 associated with high levels of Hb F in homozygotes. The clinical course of the anemia suggests that this population consists of the severe Mediterranean type. Twenty-three unrelated homozygous beta-thalassemia patients investigated for globin synthetic ratios, consisted of 18 beta+ and 5 beta 0 with a non-alpha/alpha range of 0.158-0.465 and 0.25-0.41, respectively. The percentage of G gamma chains in Hb F was determined for 21 of these patients and a mean value of 59% G gamma chain content was found.