人巨噬细胞的激活。其他细胞因子与γ干扰素的比较。
Activation of human macrophages. Comparison of other cytokines with interferon-gamma.
作者信息
Nathan C F, Prendergast T J, Wiebe M E, Stanley E R, Platzer E, Remold H G, Welte K, Rubin B Y, Murray H W
出版信息
J Exp Med. 1984 Aug 1;160(2):600-5. doi: 10.1084/jem.160.2.600.
Abstract
Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.
摘要
筛选影响单核吞噬细胞的细胞因子，以激活人类巨噬细胞分泌过氧化氢并杀死弓形虫。与重组干扰素-γ（rIFNγ）相反，以下以部分纯化或高度纯化形式在广泛浓度范围内测试的因子并未增强这些功能：天然干扰素-α（nIFNα）、rIFNαA、rIFNαD、rIFNβ、集落刺激因子（1型）（CSF-1）、粒细胞和巨噬细胞集落刺激因子（GM-CSF）、多能集落刺激因子（p-CSF）、肿瘤坏死因子（TNF）、天然白细胞介素2（nIL-2）和rIL-2。部分纯化的迁移抑制因子（MIF）在未诱导抗弓形虫活性的情况下，最大程度地增强了过氧化氢释放能力，值得进一步研究。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Purification of guinea pig pH 3 migration inhibitory factor.豚鼠pH 3迁移抑制因子的纯化
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4088-91. doi: 10.1073/pnas.78.7.4088.
3
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.单核吞噬细胞的存活依赖于一种谱系特异性生长因子，而分化细胞会选择性地破坏这种因子。
Cell. 1982 Jan;28(1):71-81. doi: 10.1016/0092-8674(82)90376-2.
4
5
Stimulation of macrophage plasminogen activator activity by colony-stimulating factors.集落刺激因子对巨噬细胞纤溶酶原激活物活性的刺激作用。
J Cell Physiol. 1980 Jun;103(3):435-45. doi: 10.1002/jcp.1041030309.
6
Effect of colony stimulating factor on murine macrophages. Induction of antitumor activity.集落刺激因子对小鼠巨噬细胞的作用。抗肿瘤活性的诱导。
J Clin Invest. 1982 Feb;69(2):270-6. doi: 10.1172/jci110449.
7
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.γ干扰素通过诱导宿主细胞降解色氨酸来阻断弓形虫在人成纤维细胞中的生长。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):908-12. doi: 10.1073/pnas.81.3.908.
8
Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.克隆的小鼠干扰素-γ可抑制普氏立克次体在培养的小鼠成纤维细胞中的生长。
J Exp Med. 1983 Dec 1;158(6):2159-64. doi: 10.1084/jem.158.6.2159.
9
Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.淋巴因子刺激的人单核吞噬细胞对细胞内杜氏利什曼原虫的杀伤作用。γ干扰素是激活淋巴因子的证据。
J Clin Invest. 1983 Oct;72(4):1506-10. doi: 10.1172/JCI111107.
10
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.鉴定γ干扰素为激活人类巨噬细胞氧化代谢和抗菌活性的淋巴因子。
J Exp Med. 1983 Sep 1;158(3):670-89. doi: 10.1084/jem.158.3.670.
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