• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Activation of human macrophages. Comparison of other cytokines with interferon-gamma.人巨噬细胞的激活。其他细胞因子与γ干扰素的比较。
J Exp Med. 1984 Aug 1;160(2):600-5. doi: 10.1084/jem.160.2.600.
2
Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.干扰素α和β对人巨噬细胞激活的激动剂和拮抗剂作用。两类干扰素γ受体以及干扰素α或β对高亲和力位点的阻断。
J Exp Med. 1988 Mar 1;167(3):1171-85. doi: 10.1084/jem.167.3.1171.
3
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.鉴定γ干扰素为激活人类巨噬细胞氧化代谢和抗菌活性的淋巴因子。
J Exp Med. 1983 Sep 1;158(3):670-89. doi: 10.1084/jem.158.3.670.
4
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma.重组粒细胞/巨噬细胞集落刺激因子激活巨噬细胞以抑制克氏锥虫并释放过氧化氢。与干扰素γ的比较。
J Exp Med. 1987 Dec 1;166(6):1734-46. doi: 10.1084/jem.166.6.1734.
5
Incorporation of recombinant gamma interferon into liposomes enhances its ability to induce peritoneal macrophage antitoxoplasma activity.将重组γ干扰素包封于脂质体中可增强其诱导腹腔巨噬细胞抗弓形虫活性的能力。
Infect Immun. 1989 Jan;57(1):132-7. doi: 10.1128/iai.57.1.132-137.1989.
6
Granulocyte-macrophage colony-stimulating factor is not involved in production of reactive nitrogen intermediates by or toxoplasmastatic activity of gamma interferon-activated murine macrophages.粒细胞-巨噬细胞集落刺激因子不参与γ干扰素激活的小鼠巨噬细胞产生反应性氮中间产物或其对弓形虫的抑制活性。
Infect Immun. 1994 Mar;62(3):1121-4. doi: 10.1128/iai.62.3.1121-1124.1994.
7
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.γ干扰素对小鼠腹腔巨噬细胞的体内外激活作用
J Immunol. 1985 Mar;134(3):1619-22.
8
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.小鼠腹腔巨噬细胞释放活性氮中间体和活性氧中间体。活化细胞因子的比较及独立产生的证据。
J Immunol. 1988 Oct 1;141(7):2407-12.
9
Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection.活化巨噬细胞抗菌活性的调节。鉴定与γ干扰素协同诱导抗感染能力的淋巴因子。
J Immunol. 1988 Aug 1;141(3):890-6.
10
Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity.
J Immunol. 1987 Sep 15;139(6):1971-7.

引用本文的文献

1
Mutual regulations between and type I interferon.与 I 型干扰素的相互调节。
Front Immunol. 2024 Jul 8;15:1428232. doi: 10.3389/fimmu.2024.1428232. eCollection 2024.
2
Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives.缺血性中风的分子机制：结合临床影像学与治疗观点的综述
Biomedicines. 2024 Apr 7;12(4):812. doi: 10.3390/biomedicines12040812.
3
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.人类 IRF1 调控巨噬细胞 IFN-γ 对分枝杆菌的免疫反应。
Cell. 2023 Feb 2;186(3):621-645.e33. doi: 10.1016/j.cell.2022.12.038.
4
Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii.陷入巨人们肩头的纳米颗粒：旧文献为刚地弓形虫的新研究提供信息。
Int J Parasitol. 2021 Dec;51(13-14):1193-1212. doi: 10.1016/j.ijpara.2021.10.004. Epub 2021 Nov 1.
5
Bioenergetic Heterogeneity in Mycobacterium tuberculosis Residing in Different Subcellular Niches.结核分枝杆菌在不同亚细胞龛位中的生物能量异质性。
mBio. 2021 Jun 29;12(3):e0108821. doi: 10.1128/mBio.01088-21. Epub 2021 Jun 1.
6
Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.人类和小鼠中 I 型 IFN 反应途径遗传缺陷的病毒感染。
Eur J Immunol. 2021 May;51(5):1039-1061. doi: 10.1002/eji.202048793. Epub 2021 Apr 4.
7
Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism.巨噬细胞在利什曼病中作为宿主、效应细胞和免疫调节细胞：组织微环境和代谢的影响
Cytokine X. 2020 Oct 12;2(4):100041. doi: 10.1016/j.cytox.2020.100041. eCollection 2020 Dec.
8
Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates.不同类型的巨噬细胞被海洋无脊椎动物来源的生物活性物质激活作为作用靶点。
Mar Drugs. 2020 Jan 2;18(1):37. doi: 10.3390/md18010037.
9
Cytokines: Key Determinants of Resistance or Disease Progression in Visceral Leishmaniasis: Opportunities for Novel Diagnostics and Immunotherapy.细胞因子：内脏利什曼病耐药或疾病进展的关键决定因素：新型诊断和免疫治疗的机会。
Front Immunol. 2019 Apr 5;10:670. doi: 10.3389/fimmu.2019.00670. eCollection 2019.
10
Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.抗中性粒细胞胞浆抗体相关性血管炎中的基因变异：贝叶斯方法与系统评价
J Clin Med. 2019 Feb 21;8(2):266. doi: 10.3390/jcm8020266.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Purification of guinea pig pH 3 migration inhibitory factor.豚鼠pH 3迁移抑制因子的纯化
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4088-91. doi: 10.1073/pnas.78.7.4088.
3
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.单核吞噬细胞的存活依赖于一种谱系特异性生长因子，而分化细胞会选择性地破坏这种因子。
Cell. 1982 Jan;28(1):71-81. doi: 10.1016/0092-8674(82)90376-2.
4
Human colony-stimulating factor (CSF-1) radioimmunoassay: resolution of three subclasses of human colony-stimulating factors.人集落刺激因子（CSF-1）放射免疫测定：人集落刺激因子三个亚类的解析
Blood. 1981 Sep;58(3):630-41.
5
Stimulation of macrophage plasminogen activator activity by colony-stimulating factors.集落刺激因子对巨噬细胞纤溶酶原激活物活性的刺激作用。
J Cell Physiol. 1980 Jun;103(3):435-45. doi: 10.1002/jcp.1041030309.
6
Effect of colony stimulating factor on murine macrophages. Induction of antitumor activity.集落刺激因子对小鼠巨噬细胞的作用。抗肿瘤活性的诱导。
J Clin Invest. 1982 Feb;69(2):270-6. doi: 10.1172/jci110449.
7
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.γ干扰素通过诱导宿主细胞降解色氨酸来阻断弓形虫在人成纤维细胞中的生长。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):908-12. doi: 10.1073/pnas.81.3.908.
8
Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.克隆的小鼠干扰素-γ可抑制普氏立克次体在培养的小鼠成纤维细胞中的生长。
J Exp Med. 1983 Dec 1;158(6):2159-64. doi: 10.1084/jem.158.6.2159.
9
Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.淋巴因子刺激的人单核吞噬细胞对细胞内杜氏利什曼原虫的杀伤作用。γ干扰素是激活淋巴因子的证据。
J Clin Invest. 1983 Oct;72(4):1506-10. doi: 10.1172/JCI111107.
10
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.鉴定γ干扰素为激活人类巨噬细胞氧化代谢和抗菌活性的淋巴因子。
J Exp Med. 1983 Sep 1;158(3):670-89. doi: 10.1084/jem.158.3.670.

人巨噬细胞的激活。其他细胞因子与γ干扰素的比较。

Activation of human macrophages. Comparison of other cytokines with interferon-gamma.

作者信息

Nathan C F, Prendergast T J, Wiebe M E, Stanley E R, Platzer E, Remold H G, Welte K, Rubin B Y, Murray H W

出版信息

J Exp Med. 1984 Aug 1;160(2):600-5. doi: 10.1084/jem.160.2.600.

DOI:10.1084/jem.160.2.600
PMID:6206183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187443/
Abstract

Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.

摘要

筛选影响单核吞噬细胞的细胞因子，以激活人类巨噬细胞分泌过氧化氢并杀死弓形虫。与重组干扰素-γ（rIFNγ）相反，以下以部分纯化或高度纯化形式在广泛浓度范围内测试的因子并未增强这些功能：天然干扰素-α（nIFNα）、rIFNαA、rIFNαD、rIFNβ、集落刺激因子（1型）（CSF-1）、粒细胞和巨噬细胞集落刺激因子（GM-CSF）、多能集落刺激因子（p-CSF）、肿瘤坏死因子（TNF）、天然白细胞介素2（nIL-2）和rIL-2。部分纯化的迁移抑制因子（MIF）在未诱导抗弓形虫活性的情况下，最大程度地增强了过氧化氢释放能力，值得进一步研究。