Takahashi Y, Akimoto R, Mai M, Ogino T, Ueda H, Kitagawa I, Kitamura T, Sawaguchi K, Bunden Y, Ueno M
Gan No Rinsho. 1984 Jul;30(8):907-11.
AFP producing cancer of the stomach was divided into 2 groups; Group A demonstrated a marked elevation of serum AFP levels before gastrectomy and was positive for AFP by PAP staining; group B showed delayed elevation of AFP levels at recurrence or in the terminal stage. Experimentally, we could establish three cell lines from group A and two lines from group B from transplanted tumor in nude mice. Tumor growth, changes of serum AFP levels and PAP staining investigated in each group. Group A and B were not only thought to exhibit different biological behavior, but also different mechanisms in AFP production. Group A cells may have the ability to secrete high levels of AFP; this may be a property of these tumor cells. On the other hand, group B tumor cells initially have little ability to secrete AFP. However, they may transform into AFP producing cells as a phenomenon of cell differentiation.
胃产甲胎蛋白癌分为两组；A组在胃切除术前血清甲胎蛋白水平显著升高，且经PAP染色甲胎蛋白呈阳性；B组在复发时或终末期甲胎蛋白水平出现延迟升高。在实验中，我们从A组裸鼠移植瘤中建立了三个细胞系，从B组中建立了两个细胞系。对每组的肿瘤生长、血清甲胎蛋白水平变化及PAP染色进行了研究。A组和B组不仅被认为表现出不同的生物学行为，而且在甲胎蛋白产生机制上也不同。A组细胞可能具有分泌高水平甲胎蛋白的能力；这可能是这些肿瘤细胞的一种特性。另一方面，B组肿瘤细胞最初分泌甲胎蛋白的能力很小。然而，它们可能作为细胞分化现象转化为产甲胎蛋白细胞。
