Drayer J I, Weber M A, Purdy R E, Lipson J L
J Cardiovasc Pharmacol. 1984;6 Suppl 2:S394-400. doi: 10.1097/00005344-198406002-00014.
Results of clinical and experimental studies suggest that extrarenal actions of corticosteroid hormones must be involved in the overall effects of these steroids on the circulation. A dissociation between levels of mineralocorticoids and sodium balance or renal effects of steroid hormones is often observed in patients with primary or secondary forms of hypertension. Receptors for various steroids have been found in the peripheral circulation. Stimulation of these receptors probably leads to changes in the electrolyte content of the cell. In turn, these changes have a direct or indirect effect on the contractility of the vascular wall. The physiological importance of the vascular effects of steroids in human hypertension remains to be elucidated.
临床和实验研究结果表明，皮质类固醇激素的肾外作用必定参与了这些类固醇对循环系统的整体影响。在原发性或继发性高血压患者中，经常观察到盐皮质激素水平与钠平衡或类固醇激素的肾脏效应之间存在分离。在周围循环中已发现各种类固醇的受体。刺激这些受体可能会导致细胞电解质含量发生变化。反过来，这些变化对血管壁的收缩性有直接或间接影响。类固醇在人类高血压中的血管效应的生理重要性仍有待阐明。
