Naafs M A, van der Velden P C, Fischer H R, Koorevaar G, van Duin S, Hackeng W H, Schopman W, Silberbusch J
Acta Endocrinol (Copenh). 1984 Aug;106(4):477-81. doi: 10.1530/acta.0.1060477.
Plasma cyclic AMP (PcAMP) concentration and the excretion of cyclic AMP/dl GF were estimated in 11 thyrotoxic patients before and after medical treatment. PcAMP concentrations were significantly higher during hyperthyroidism (2.30 +/- 0.69 vs 1.88 +/- 0.71 nmol/dl; P less than 0.05), and total urinary cyclic AMP (TcAMP) excretion showed no significant changes (3.24 +/- 0.64 vs 3.44 +/- 1.77 nmol/dl GF). Nephrogenous (NcAMP) excretion rose significantly (1.00 +/- 0.82 vs 1.68 +/- 1.31 mmol/dl GF; P less than 0.025). The increase in NcAMP excretion correlated significantly with the decrease in serum T3 levels (r = -0.46; P less than 0.05). Serum iPTH levels showed no significant change. Both the serum Ca, corrected for serum total protein and TmPO4/GFR declined after treatment (respectively 2.44 +/- 0.13 vs 2.33 +/- 0.08 mmol/l; P less than 0.05 and 1.18 +/- 0.29 vs 1.05 +/- 0.22 mmol/l; P less than 0.05). It is concluded that the rise in NcAMP excretion corroborates the concept of increasing parathyroid activity following the treatment of hyperthyroidism.
对11例甲状腺毒症患者在药物治疗前后的血浆环磷酸腺苷（PcAMP）浓度及每分升肾小球滤过液中环磷酸腺苷（cAMP）的排泄量进行了评估。甲状腺功能亢进期间PcAMP浓度显著升高（2.30±0.69对1.88±0.71nmol/dl；P＜0.05），而尿中环磷酸腺苷总量（TcAMP）排泄无显著变化（3.24±0.64对3.44±1.77nmol/dl肾小球滤过液）。肾源性（NcAMP）排泄显著升高（1.00±0.82对1.68±1.31mmol/dl肾小球滤过液；P＜0.025）。NcAMP排泄的增加与血清T3水平的降低显著相关（r = -0.46；P＜0.05）。血清甲状旁腺激素（iPTH）水平无显著变化。治疗后，校正血清总蛋白后的血清钙及TmPO4/GFR均下降（分别为2.44±0.13对2.33±0.08mmol/L；P＜0.05和1.18±0.29对1.05±0.22mmol/L；P＜0.05）。结论是，NcAMP排泄的增加证实了甲状腺功能亢进治疗后甲状旁腺活性增加的概念。
