Hartveit F, Thoresen S, Tangen M, Maartmann-Moe H
Invasion Metastasis. 1984;4(3):146-55.
In breast carcinoma metachromasia on staining the primary tumour with toluidine blue is related to mast cell changes and an infiltrative as opposed to an expansive growth form. In 73 patients the presence of metachromasia in the zone of host-tumour interaction, just beyond the edge of the tumour cells, was associated with poor short-term survival, giving greater discrimination than, for example, axillary nodal status or histological grade. 12 of 19 patients with metachromasia in this zone died within 5 years of operation. This indicates that the reaction is not only related to local infiltrative growth, but may also reflect the tumour potential for metastatic spread. In the absence of metachromasia in this zone death occurred mainly in patients with poorly differentiated tumours. The possible mechanisms involved are discussed. It is stressed that stromal metachromasia is not tumour specific, but that in certain areas, under defined circumstances, it may give information of both prognostic and biological interest.
在乳腺癌中，用甲苯胺蓝对原发性肿瘤进行染色时出现的异染性与肥大细胞变化以及浸润性生长形式（而非膨胀性生长形式）有关。在73例患者中，在宿主 - 肿瘤相互作用区域（就在肿瘤细胞边缘之外）出现异染性与短期生存率低相关，其鉴别能力比例如腋窝淋巴结状态或组织学分级更强。在该区域有19例出现异染性的患者中，有12例在手术后5年内死亡。这表明该反应不仅与局部浸润性生长有关，还可能反映肿瘤转移扩散的潜能。在该区域无异染性的情况下，死亡主要发生在肿瘤分化差的患者中。文中讨论了其中可能涉及的机制。强调基质异染性并非肿瘤特异性的，但在某些特定情况下，它可能提供有关预后和生物学方面的信息。
