Simon M C, Smith R E, Hayward W S
J Virol. 1984 Oct;52(1):1-8. doi: 10.1128/JVI.52.1.1-8.1984.
Subgroup F avian leukosis viruses, such as RAV-61 and ring-necked pheasant virus, are recombinants between exogenous chicken retroviruses and endogenous pheasant viruses and contain new envelope (env) genes. Chickens infected as 10-day-old embryos with subgroup F viruses develop fibrosarcomas, nephroblastomas, osteopetrosis, B-cell lymphomas, and a high incidence of a proliferative disorder involving the lung. Fibrosarcomas, nephroblastomas, and lymphomas appear after long latent periods (3 to 12 months). They contain discrete virus-cell junction fragments and are therefore clonal outgrowths of a single infected cell. Two ring-necked pheasant virus-induced B-cell lymphomas and an adenocarcinoma of the abdomen contained proviruses integrated at the c-myc locus and elevated levels of myc mRNA. At least four of the fibrosarcomas appeared to contain proviruses integrated at a common site, suggesting that a specific cellular gene may be involved in these tumors. The host gene has not been identified, however; 16 different oncogene probes failed to hybridize to fibrosarcoma junction fragments. In contrast to these neoplasms, lung lesions appeared rapidly (4 to 5 weeks), showed no evidence of clonality, and lacked long terminal repeat-initiated transcripts other than viral 35S and 21S mRNA. We conclude, therefore, that subgroup F retroviruses induce the proliferative disorder of the lung by a different mechanism.
F亚群禽白血病病毒，如RAV - 61和环颈雉病毒，是外源性鸡逆转录病毒与内源性雉病毒之间的重组体，含有新的包膜（env）基因。10日龄胚胎感染F亚群病毒的鸡会发生纤维肉瘤、肾母细胞瘤、骨质石化、B细胞淋巴瘤，以及肺部增殖性疾病的高发病率。纤维肉瘤、肾母细胞瘤和淋巴瘤在较长潜伏期（3至12个月）后出现。它们含有离散的病毒 - 细胞连接片段，因此是单个感染细胞的克隆性增殖。两例环颈雉病毒诱导的B细胞淋巴瘤和一例腹部腺癌含有整合在c - myc基因座的前病毒以及升高水平的myc mRNA。至少有四个纤维肉瘤似乎含有整合在一个共同位点的前病毒，这表明一个特定的细胞基因可能与这些肿瘤有关。然而，宿主基因尚未确定；16种不同的癌基因探针未能与纤维肉瘤连接片段杂交。与这些肿瘤不同，肺部病变出现迅速（4至5周），没有克隆性的证据，并且除了病毒35S和21S mRNA外，缺乏长末端重复序列起始的转录本。因此，我们得出结论，F亚群逆转录病毒通过不同机制诱导肺部增殖性疾病。
