Kérouac R, St-Pierre S, Rioux F
Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):309-12.
We have assessed the influence of forskolin, a potent activator of adenylate cyclase, on histamine release by neurotensin (NT) in the rat perfused hind limb. The results indicate that forskolin, in concentrations known to increase the cyclic AMP content of various tissues, markedly inhibits the histamine releasing effect of NT. The inhibitory action of forskolin was mimicked by a synthetic cyclic AMP derivative and by 3-isobutyl-1-methyl-xanthine (IBMX), a potent phosphodiesterase inhibitor. Our results suggest that the inhibitory action of forskolin toward histamine release by NT in the rat hind limb mast cells results from the activation of a cyclic AMP-generating system in mast cells.
我们评估了强效腺苷酸环化酶激活剂福斯高林对大鼠灌注后肢中神经降压素（NT）诱导的组胺释放的影响。结果表明，福斯高林在已知能增加各种组织中环磷酸腺苷（cAMP）含量的浓度下，能显著抑制NT的组胺释放作用。一种合成的cAMP衍生物和强效磷酸二酯酶抑制剂3-异丁基-1-甲基黄嘌呤（IBMX）可模拟福斯高林的抑制作用。我们的结果表明，福斯高林对大鼠后肢肥大细胞中NT诱导的组胺释放的抑制作用源于肥大细胞中cAMP生成系统的激活。
