Nicosia R F, McCormick J F, Bielunas J
Scan Electron Microsc. 1984(Pt 2):793-9.
Rings of rat aorta cultured in plasma clots gave rise to microvascular networks. Scanning electron microscopy revealed that, in most cultures, the newly formed microvessels communicated with an endothelial-lined chamber which had developed around the aorta. The endothelial cells lining the wall of this chamber were elongated and frequently overlapped each other forming unicellular or multicellular bridges. The endothelium also produced solid bands and webs which spanned wide regions of the periaortic chamber and of the aortic lumen. Solid endothelial ropelike structures overran the openings of the newly formed vascular channels and connected the outer wall of the chamber with the aortic ring. Webs were composed of branching cords of spiraling endothelial cells with or without collagenized cores. Webs and bands formed as a result of the extensive surface remodeling of the fibrin clot by developing endothelial channels. These structures are reminiscent of the intimal bands and webs which develop in human blood vessels as a late sequela of the organization of thromboemboli.
在血浆凝块中培养的大鼠主动脉环形成了微血管网络。扫描电子显微镜显示，在大多数培养物中，新形成的微血管与围绕主动脉形成的内皮衬里腔室相通。衬于该腔室壁的内皮细胞拉长，且经常相互重叠形成单细胞或多细胞桥。内皮还产生横跨主动脉周围腔室和主动脉管腔广泛区域的实心带和网。实心的内皮绳状结构越过新形成的血管通道开口，将腔室外壁与主动脉环相连。网由带有或不带有胶原化核心的螺旋状内皮细胞分支索组成。网和带是由发育中的内皮通道对纤维蛋白凝块进行广泛表面重塑而形成的。这些结构让人联想到人类血管中作为血栓栓塞机化的晚期后遗症而形成的内膜带和网。
