Leclerq J F, Maisonblanche P, Cauchemez B, Attuel P, Coumel P
Arch Mal Coeur Vaiss. 1984 Aug;77(8):937-45.
The authors studied 32 patients with ventricular arrhythmias--ventricular tachycardia (VT) or frequent ventricular extrasystoles (VES) and/or runs of extrasystole and cardiomyopathy with dilatation. This diagnosis was retained on the following criteria: absence of angina or electrical changes in infarction, normal coronary angiography in patients over the age of 50, diffuse abnormalities of ventricular contraction on 2D echocardiography or angiography, and on the absence of organic valvular heart disease. Thirteen patients had sustained paroxysmal VT, 18 patients had runs of VT and only 8 patients had isolated VES without repetition. The arrhythmia was polymorphic in 25 patients. All possible combinations of morphology of right of left sided delay with variable axes were observed. There were 25 right sided delays and 18 left sided delays; the association of left sided delay and vertical axis was only present in 5 occasions. Twelve patients underwent electrophysiological investigations for sustained VT but the arrhythmia could only be induced by ventricular extrastimulation in 4 cases. Eight patients were investigated during VT; the arrhythmia could only be terminated easily in 2 cases. Three of these 12 patients had biventricular tachycardia. Of the 11 patients with chronic alcoholism, only 2 had sustained VT, 8 had polymorphic VES and 1 monomorphic VES. Conversely, of the 21 patients without alcoholism, 11 had sustained VT, 6 had polymorphic VES, and 4 had monomorphic VES. There was a correlation between the polymorphism of the arrhythmia and the degree of ventricular dysfunction: of the 16 patients in overt cardiac failure (EF less than 30%), only 1 had monomorphic VT; the 15 others all had polymorphic arrhythmias. Only 2 had sustained VT.(ABSTRACT TRUNCATED AT 250 WORDS)
作者研究了32例室性心律失常患者——室性心动过速(VT)或频发室性早搏(VES)和/或早搏连发以及扩张型心肌病患者。该诊断基于以下标准:无心绞痛或梗死的电变化,50岁以上患者冠状动脉造影正常,二维超声心动图或血管造影显示心室收缩弥漫性异常,且无器质性瓣膜性心脏病。13例患者有持续性阵发性VT,18例患者有VT连发,仅8例患者有孤立性VES且无重复。25例患者的心律失常为多形性。观察到左右束支传导延迟形态与不同电轴的所有可能组合。有25例右侧束支传导延迟和18例左侧束支传导延迟;左侧束支传导延迟与垂直电轴的关联仅出现5次。12例患者因持续性VT接受了电生理检查,但仅4例患者的心律失常可通过心室额外刺激诱发。8例患者在VT发作时接受检查;仅2例患者的心律失常可轻易终止。这12例患者中有3例为双心室心动过速。在11例慢性酒精中毒患者中,仅2例有持续性VT,8例有多形性VES,1例有单形性VES。相反,在21例无酒精中毒的患者中,11例有持续性VT,6例有多形性VES,4例有单形性VES。心律失常的多形性与心室功能障碍程度之间存在相关性:在16例明显心力衰竭(射血分数小于30%)的患者中,仅1例有单形性VT;其他15例均有多形性心律失常。仅2例有持续性VT。(摘要截选至250字)