Leung L S
Electroencephalogr Clin Neurophysiol. 1984 Nov;58(5):457-66.
Electrodes implanted in stratum radiatum of CA1 region in freely moving rats gave a theta phase shift of 120-150 degrees with respect to an alvear electrode. Various centrally acting drugs were shown to shift the radiatum theta phase. Among the conditions giving an upward shift in the order of decreasing phase: values are: immobility under anesthetic doses of ether and urethane (phase close to 180 degrees), immobility under eserine, 'struggling' under sub-anesthetic dose of urethane, walking after phencyclidine, and walking after reserpine, eserine and pentobarbital. After atropine or scopolamine, the phase shifted downward by 10-30 degrees. The rank order of radiatum theta phase amplitude may correspond to the balance between two pharmacological and anatomical distinct pathways which give rise to the theta rhythm, i.e., the atropine-sensitive and atropine-resistant inputs. Large phases, close to 180 degrees, indicate a large ratio of the atropine-sensitive over the atropine-resistant input, and small phases a small ratio. Phase measurement of the theta rhythm therefore provides a sensitive functional measurement of the dynamic balance of the two theta inputs.
植入自由活动大鼠CA1区辐射层的电极相对于海马槽电极会产生120 - 150度的θ相位偏移。各种中枢作用药物都显示能改变辐射层θ相位。在导致相位上升（按相位减小顺序排列）的各种条件下：数值如下：在麻醉剂量的乙醚和乌拉坦作用下静止不动（相位接近180度）、在毒扁豆碱作用下静止不动、在亚麻醉剂量的乌拉坦作用下“挣扎”、在苯环利定作用后行走、以及在利血平、毒扁豆碱和戊巴比妥作用后行走。在阿托品或东莨菪碱作用后，相位向下偏移10 - 30度。辐射层θ相位幅度的排序可能对应于产生θ节律的两条药理学和解剖学上不同的通路之间的平衡，即对阿托品敏感和对阿托品不敏感的输入。接近180度的大相位表明对阿托品敏感的输入相对于对阿托品不敏感的输入比例大，而小相位则表明比例小。因此，θ节律的相位测量为两个θ输入的动态平衡提供了一种灵敏的功能测量方法。
