稀释皮质类固醇乳膏的防腐活性。

Preservative activity in diluted corticosteroid creams.

作者信息

Hugo W B, Denyer S P, York H L, Tucker J D

出版信息

J Hosp Infect. 1984 Sep;5(3):329-33. doi: 10.1016/0195-6701(84)90083-5.

PMID:6208253

Abstract

The preservative efficacy of both 'Betnovate' and 'Synalar' creams diluted 1:1 with 'Unguentum Merck' was investigated. Each formulation was challenged with Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa at an initial inoculum level of approximately 1 X 10(6) viable organisms per gram of cream. All formulations tested were found to be effectively preserved against the organisms used and no viable bacteria were detected 7 days after inoculation.

摘要

研究了用“默克凡士林”按1:1稀释的“倍他米松新霉素乳膏”和“仙乃乐乳膏”的防腐效果。每种配方均以每克乳膏约1×10⁶个活生物体的初始接种水平接种大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌。所测试的所有配方均被发现对所用微生物有有效的防腐作用，接种7天后未检测到活菌。