Cappelli V, Forni R, Poggesi C, Reggiani C, Ricciardi L
Arch Int Physiol Biochim. 1984 Aug;92(2):93-106. doi: 10.3109/13813458409071133.
A parallel investigation on collagen content and diastolic mechanical properties has been performed on myocardial specimens isolated from male albino Wistar rats of different age groups (1-5 days, 10-20 days, 2 months, 8 months, 18 months, 24-26 months). Total water content, inulin-distribution space, protein concentration were determined together with hydroxyprolin content of the tissue. Mechanical properties of isolated papillary muscles were characterized in terms of static, dynamic, and plastic response to strain. During maturation (from birth to 2 months) the increase of collagen content is paralleled by an increase of static elasticity and by a reduction of plasticity. During maturity (2-8 months) and ageing (8-26 months) the collagen concentration in myocardial tissue still increases, but this change is associated to a reduction of the static components and to an increase of dynamic components of myocardial stiffness. A comparison between specimens from right and left ventricular myocardium indicates that a higher collagen content in the right ventricle is associated with a higher static elasticity.
对从不同年龄组（1 - 5天、10 - 20天、2个月、8个月、18个月、24 - 26个月）的雄性白化Wistar大鼠分离出的心肌标本进行了胶原蛋白含量与舒张期力学性能的平行研究。测定了组织的总含水量、菊粉分布空间、蛋白质浓度以及羟脯氨酸含量。分离出的乳头肌的力学性能通过对应变的静态、动态和塑性反应来表征。在成熟过程中（从出生到2个月），胶原蛋白含量的增加与静态弹性的增加和塑性的降低同时出现。在成熟期（2 - 8个月）和衰老期（8 - 26个月），心肌组织中的胶原蛋白浓度仍在增加，但这种变化与心肌僵硬度的静态成分降低和动态成分增加有关。右心室和左心室心肌标本的比较表明，右心室中较高的胶原蛋白含量与较高的静态弹性相关。
