1,10-菲咯啉可逆性抑制两种人前列腺癌细胞系（PC-3和DU145）的增殖。
1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145).
作者信息
Ware J L, Paulson D F, Webb K S
出版信息
Biochem Biophys Res Commun. 1984 Oct 30;124(2):538-43. doi: 10.1016/0006-291x(84)91587-0.
PMID:6208907
Abstract
The metal chelator 1,10-phenanthroline reversibly inhibits proliferation of two human prostate carcinoma cell lines, PC-3 and DU145. Inhibition is dose-dependent, and persists for several days after removal of the chelator. The ability to induce reversible quiescence in human prostate carcinoma cells in vitro may facilitate the study of their growth cycle biochemistry.
摘要
金属螯合剂1,10-菲咯啉可可逆地抑制两种人前列腺癌细胞系PC-3和DU145的增殖。抑制作用呈剂量依赖性，且在去除螯合剂后持续数天。在体外诱导人前列腺癌细胞可逆性静止的能力可能有助于对其生长周期生物化学的研究。
Zotero 插件