[脑血管的肽能神经支配——一项免疫组织化学研究]
[Peptidergic innervation of the cerebral blood vessels--an immunohistochemical study].
作者信息
Itakura T, Okuno T, Nakakita K, Naka Y, Kamei I, Nakai K, Imai H, Komai N, Kimura H, Maeda T
出版信息
No To Shinkei. 1984 Aug;36(8):767-73.
By an immunohistochemical technique, vasoactive polypeptide (VIP)-and substance P-containing nerve fibers are observed in the cerebral blood vessels. VIP-containing nerve fibers distribute in a spiral pattern, similar to the muscle cell distribution pattern. Under an electron microscopic observation, VIP-immunoreactive terminals lie just near to a muscle cell in the inner layer of the adventitia. In contrast, substance P-containing nerve fibers show a meshwork pattern in the outer layer of the adventitia. In combination of acetylcholinesterase (AChE) staining and VIP immunohistochemistry, AChE-positive and VIP-immunoreactive nerve fibers reveal almost same distribution in the same specimen. The present data suggest that VIP-containing nerve fibers may play a role of smooth muscle control of the blood vessels, while substance P-containing nerve fibers may not take part in muscle control.
通过免疫组织化学技术，在脑血管中观察到含有血管活性多肽（VIP）和P物质的神经纤维。含VIP的神经纤维呈螺旋状分布，类似于肌肉细胞的分布模式。在电子显微镜观察下，VIP免疫反应性终末位于外膜内层的肌肉细胞附近。相比之下，含P物质的神经纤维在外膜外层呈网状分布。在乙酰胆碱酯酶（AChE）染色和VIP免疫组织化学相结合的情况下，AChE阳性和VIP免疫反应性神经纤维在同一样本中显示出几乎相同的分布。目前的数据表明，含VIP的神经纤维可能在血管平滑肌控制中发挥作用，而含P物质的神经纤维可能不参与肌肉控制。
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