Safi F, Büchler M, Schenkluhn B, Beger H G
Dtsch Med Wochenschr. 1984 Dec 7;109(49):1869-73. doi: 10.1055/s-2008-1069469.
The diagnostic value of the tumour-associated antigen CA 19-9 was tested in 309 patients, 156 with malignancies (39 carcinoma of the pancreas, 117 extrapancreatic malignant tumour) and 153 patients with non-malignant disease (54 chronic pancreatitis, 25 acute pancreatitis, 74 general surgical disease). Levels above the normal range of 6-37 U/ml were obtained in 95% of patients with carcinoma of the pancreas (mean value 528 U/ml), in 31% of patients with gastric carcinoma and 16% with colorectal carcinoma (mean 8 U/ml). Results of the pre-operative determination of CA 19-9 indicated for carcinoma of the pancreas a sensitivity of 95%, a specificity of 87% and an overall accuracy of 88%. Pre-operatively elevated CA 19-9 concentrations in patients with carcinoma of the pancreas fell to normal after curative resection of the neoplasm. After palliative operation or in inoperable carcinoma CA 19-9 serum concentrations were never less than 37 U/ml.
在309例患者中检测了肿瘤相关抗原CA 19-9的诊断价值，其中156例为恶性肿瘤患者（39例胰腺癌、117例胰腺外恶性肿瘤），153例为非恶性疾病患者（54例慢性胰腺炎、25例急性胰腺炎、74例普通外科疾病）。95%的胰腺癌患者CA 19-9水平高于6 - 37 U/ml的正常范围（平均值528 U/ml），31%的胃癌患者及16%的结直肠癌患者CA 19-9水平高于正常范围（平均值8 U/ml）。术前CA 19-9测定结果显示，胰腺癌的敏感性为95%，特异性为87%，总体准确率为88%。胰腺癌患者术前升高的CA 19-9浓度在肿瘤根治性切除后降至正常。姑息性手术后或无法手术切除的癌症患者，CA 19-9血清浓度从未低于37 U/ml。
