Denes P
Pacing Clin Electrophysiol. 1984 Nov;7(6 Pt 2):1108-14. doi: 10.1111/j.1540-8159.1984.tb05669.x.
The effect of cycle length upon refractory period of the atria was measured in 34 patients. The effect of abrupt change in paced cycle length on atrial refractory period was measured by introducing after every eighth paced cycle (CLP) a test cycle (CLT) at an interval which was either 100 ms longer (CLT = CLP + 100 ms) or shorter (CLT = CLP - 100 ms) than the paced cycle. These findings confirm that: (1) atrial refractory periods shorten with decreasing cycle length during steady state pacing; (2) an abrupt change in paced cycle length results in a change in refractory period. This change is similar in direction but smaller in magnitude than the change which occurs in response to steady state pacing; and (3) there is no correlation between intraatrial conduction time and refractoriness.
在34例患者中测量了周期长度对心房不应期的影响。通过在每八个起搏周期（CLP）之后引入一个测试周期（CLT）来测量起搏周期长度突然变化对心房不应期的影响，该测试周期与起搏周期相比，间隔要么长100毫秒（CLT = CLP + 100毫秒），要么短100毫秒（CLT = CLP - 100毫秒）。这些发现证实：（1）在稳定状态起搏期间，心房不应期随周期长度的缩短而缩短；（2）起搏周期长度的突然变化导致不应期的改变。这种变化在方向上相似，但幅度小于对稳定状态起搏的反应所发生的变化；（3）心房内传导时间与不应性之间没有相关性。
