Cochran R C, Wiedow M A
Toxicol Appl Pharmacol. 1984 Dec;76(3):519-25. doi: 10.1016/0041-008x(84)90356-9.
The reproductive toxicity of chlordecone has been hypothesized to derive from estrogen mimicry. To test this hypothesis, the effects of estradiol-17 beta, testosterone, and chlordecone on the male reproductive tract of 60-day-old male rats were compared after 72 days of exposure. Estradiol-17 beta (25 micrograms/week) and testosterone (945 micrograms/week), administered by polydimethylsiloxane capsules implanted subdermally, caused significant reductions in spermatogenesis, sperm motility, testicular capacity for secreting testosterone, and the weights of testes and epididymides. Estradiol-17 beta also caused significant declines in serum testosterone concentrations, and the weight of the prostate and seminal vesicles. Chlordecone, administered either by polydimethylsiloxane capsule or by ip injection, had no effect on any of these parameters, except to reduce significantly seminal vesicle weight at the highest dose of injected chlordecone, 7.5 mg/week. Therefore, chlordecone does not mimic estrogen in its effects on the reproductive system of the male rat.
开蓬的生殖毒性被推测源于其雌激素模拟作用。为验证这一假设，在暴露72天后，比较了雌二醇 - 17β、睾酮和开蓬对60日龄雄性大鼠雄性生殖道的影响。通过皮下植入聚二甲基硅氧烷胶囊给予雌二醇 - 17β（25微克/周）和睾酮（945微克/周），可导致精子发生、精子活力、睾丸分泌睾酮的能力以及睾丸和附睾重量显著降低。雌二醇 - 17β还可导致血清睾酮浓度以及前列腺和精囊重量显著下降。通过聚二甲基硅氧烷胶囊或腹腔注射给予开蓬，除了在最高注射剂量（7.5毫克/周）的开蓬下精囊重量显著降低外，对上述任何参数均无影响。因此，开蓬对雄性大鼠生殖系统的作用并不模拟雌激素。
