Remick D G, Kumar N B
Am J Surg Pathol. 1984 Nov;8(11):833-9. doi: 10.1097/00000478-198411000-00003.
The clinicohistologic features of seven urethral and four urinary bladder polyps with prostatic-type epithelium are described. The average age of the patients was 50 years. Seven patients had prior cystoscopies and in none of them was the lesion noted initially. Histologically the lesions were papillary or polypoid and the surface was lined predominantly by prostatic-type epithelium with interspersed transitional epithelial cells or by transitional epithelium with interspersed prostatic-type epithelial cells. The prostatic-type columnar cells contained foamy, faintly eosinophilic cytoplasm, which stained strongly for prostate specific antigen and prostatic acid phosphatase. In all the lesions, there were prostatic acini in the underlying fibrovascular stroma, which was devoid of smooth muscle. The intermingling of prostatic-type cells and transitional epithelium, on the surface of the polyps, the absence of lesions at previous cystoscopies, the coexistence of cystitis cystica glandularis (a metaplastic lesion), and the older age group of our patients suggest that the prostatic-type epithelium in the polyps of urethra and urinary bladder is an acquired lesion, most likely a metaplastic response of transitional epithelium, which embryologically was multipotential.
本文描述了7例尿道息肉和4例膀胱息肉伴前列腺型上皮的临床组织学特征。患者的平均年龄为50岁。7例患者曾接受过膀胱镜检查，最初均未发现病变。组织学上，病变呈乳头状或息肉状，表面主要由前列腺型上皮衬覆，其间散在移行上皮细胞，或由移行上皮衬覆，其间散在前列腺型上皮细胞。前列腺型柱状细胞含有泡沫状、淡嗜酸性细胞质，对前列腺特异性抗原和前列腺酸性磷酸酶染色强烈。在所有病变中，其下方的纤维血管间质中存在前列腺腺泡，且无平滑肌。息肉表面前列腺型细胞与移行上皮的混合、既往膀胱镜检查时无病变、腺性膀胱炎（一种化生病变）的并存以及患者年龄较大，提示尿道和膀胱息肉中的前列腺型上皮是一种后天性病变，很可能是移行上皮的化生反应，而移行上皮在胚胎学上具有多潜能性。
