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Genetic factors in affective illness.

作者信息

Berrettini W H, Goldin L R, Nurnberger J I, Gershon E S

出版信息

J Psychiatr Res. 1984;18(4):329-50. doi: 10.1016/0022-3956(84)90024-4.

DOI:10.1016/0022-3956(84)90024-4
PMID:6210359
Abstract

Research strategies for determining genetic vulnerability markers in affective illness are delineated. Using these strategies, recent developments in the biology of manic-depressive illness are discussed, including results from association and linkage studies, pharmacologic challenge protocols, and cerebrospinal fluid (CSF) data. Several lines of evidence suggest that one genetically determined vulnerability to affective disorder may be a cholinergic supersensitivity, possibly mediated through increased numbers of cholinergic receptors.

摘要

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