Latif R, Thirumoorthi M C, Buckley J A, Kobos D M, Aravind M K, Kauffman R E, Dajani A S
Dev Pharmacol Ther. 1981;3(4):222-31. doi: 10.1159/000457446.
37 patients ranging in age from 9 months to 14 years, with various infections, were treated with moxalactam. The pharmacokinetics of the drug were studied in 18 patients. The mean plasma concentration 1 h after a 25 mg/kg intravenous dose was 41.4 micrograms/ml +/- 15.6 SD, the half-life was 1.5 h +/- 0.4 SD and the mean Vd was 550 ml/kg +/- 239 SD. The total body clearance of moxalactam was 4.1 ml/min/kg +/- 1.5 SD and the mean renal clearance 4.5 ml/min/kg +/- 2.8 SD. Between 52 and 107% of the administered dose was recovered in the urine within 8 h after administration. The pharmacokinetics after the first and multiple doses of moxalactam were similar, indicating no accumulation of the drug with repeated administration. The clinical response was adequate in 35 of 37 patients. Moxalactam was well tolerated and only minor and transient hematological abnormalities were observed.
37例年龄从9个月至14岁、患有各种感染的患者接受了拉氧头孢治疗。对其中18例患者进行了该药的药代动力学研究。静脉注射剂量为25mg/kg后1小时的平均血浆浓度为41.4μg/ml±15.6标准差，半衰期为1.5小时±0.4标准差，平均分布容积为550ml/kg±239标准差。拉氧头孢的总体清除率为4.1ml/（min·kg）±1.5标准差，平均肾清除率为4.5ml/（min·kg）±2.8标准差。给药后8小时内，52%至107%的给药剂量在尿液中回收。拉氧头孢首剂和多剂后的药代动力学相似，表明反复给药后该药无蓄积。37例患者中有35例临床反应良好。拉氧头孢耐受性良好，仅观察到轻微和短暂的血液学异常。
