Schindler G, Küper K
Rofo. 1982 Jan;136(1):64-74. doi: 10.1055/s-2008-1055997.
Fifty-three patients with biliary symptoms were studied at least four years after cholecystectomy by isotope techniques. There was a highly significant correlation between symptoms and disturbances of bile flow, such as dyskinesia or obstruction. There was no correlation with serum enzyme levels such as gamma-GT, alkaline phosphatase, bilirubin or transaminases. Measurements of the diameter of the bile duct on cholangiograms provided no evidence of obstruction up to 15 mm., although a diameter in excess of 10 mm, made obstruction likely. The upper value for "normal" bile flow derived from hilar flow curves of patients without dyskinesia showed a half value period of 27.5 minutes. The disturbances of flow demonstrated by isotope methods in the presence of typical symptoms, and without other pathological findings, indicate a pre-clinical stage of a partly compensated bilio dynamic insufficiency. Where there is no morphological evidence of biliary obstruction, one must assume inflammatory changes round the papilla of Vater; these are frequent even in normal biliary tracts and almost always present after cholecystectomy. Quantitative hepato-biliary scintigraphy is the most reliable method for objective measurement of disturbances of bile flow and make it possible to avoid the vague diagnosis of "post-cholecystectomy syndrome".
采用同位素技术对53例胆囊切除术后至少四年仍有胆系症状的患者进行了研究。症状与胆汁流动障碍(如运动障碍或梗阻)之间存在高度显著的相关性。与γ-GT、碱性磷酸酶、胆红素或转氨酶等血清酶水平无关。胆管造影测量胆管直径,在直径达15mm时未发现梗阻证据,尽管直径超过10mm时梗阻可能性增加。无运动障碍患者肝门血流曲线得出的“正常”胆汁流动上限值显示半衰期为27.5分钟。在存在典型症状且无其他病理发现的情况下,同位素方法显示的血流障碍表明存在部分代偿性胆汁动力学不足的临床前期阶段。在无胆道梗阻形态学证据的情况下,必须假定Vater壶腹周围存在炎症改变;这些改变即使在正常胆道中也很常见,在胆囊切除术后几乎总是存在。定量肝胆闪烁扫描是客观测量胆汁流动障碍最可靠的方法,可避免“胆囊切除术后综合征”的模糊诊断。