Krízala J, Kovárová H, Stoklasová A, Ledvina M
Physiol Bohemoslov. 1982;31(2):151-7.
The activity of superoxide dismutase (E.C. 1.15.1.1; SOD) was determined in male Wistar rats in order to evaluate the possible relationship between both the enzyme content in tissue and the resistance of this tissue to ionizing radiation (8,0 Gy, 60Co). Our results showed that some non-irradiated radioresistant organs (liver) had a high SOD activity and on the contrary, in some radiosensitive tissue (bone marrow) the SOD content was low. In spite of this observation it is not possible to generalize the statement that the radiosensitivity is directly conditioned by the SOD level without any exception. The SOD content in the spleen was higher than in the brain, but the spleen is remarkably radiosensitive, whereas the brain is not. The radiosensitivity of individual tissues probably reflected the changes of SOD activity after the irradiation.
为了评估组织中的超氧化物歧化酶（E.C. 1.15.1.1；SOD）含量与该组织对电离辐射（8.0 Gy，60Co）的抗性之间可能存在的关系，对雄性Wistar大鼠的超氧化物歧化酶活性进行了测定。我们的结果表明，一些未受辐射的抗辐射器官（肝脏）具有较高的SOD活性，相反，在一些辐射敏感组织（骨髓）中，SOD含量较低。尽管有此观察结果，但不可能一概而论地说辐射敏感性直接由SOD水平决定而毫无例外。脾脏中的SOD含量高于大脑，但脾脏对辐射非常敏感，而大脑则不然。各个组织的辐射敏感性可能反映了辐射后SOD活性的变化。
