由补体依赖性IgG抗体介导的对硫酸鱼精蛋白的过敏反应。

Anaphylaxis to protamine sulfate mediated by a complement-dependent IgG antibody.

作者信息

Lakin J D, Blocker T J, Strong D M, Yocum M W

出版信息

J Allergy Clin Immunol. 1978 Feb;61(2):102-7. doi: 10.1016/0091-6749(78)90232-4.

Abstract

Anaphylactoid reactions to protamine sulfate have been attributed to its capacity for nonimmunologic mast cell degranulation and/or complement consumption. In the current study, evidence is presented for the occurrence of an immunologic anaphylactic reaction mediated by a complement-dependent IgG skin-sensitizing antibody. A retrospective study of blood component donors given protamine for heparin neutralization revealed that prior exposure to protamine is associated with increased risk of adverse reaction to the drug.

摘要

硫酸鱼精蛋白的类过敏反应被认为与其引起非免疫性肥大细胞脱颗粒和/或补体消耗的能力有关。在本研究中，有证据表明存在由补体依赖性IgG皮肤致敏抗体介导的免疫性过敏反应。一项对接受鱼精蛋白以中和肝素的血液成分捐献者的回顾性研究表明，先前接触过鱼精蛋白会增加对该药物不良反应的风险。