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体外循环后一名儿童对鱼精蛋白的补体激活及类过敏反应。

Complement activation and anaphylactoid response to protamine in a child after cardiopulmonary bypass.

作者信息

Westaby S, Turner M W, Stark J

出版信息

Br Heart J. 1985 May;53(5):574-6. doi: 10.1136/hrt.53.5.574.

Abstract

A 2 1/2 year old boy had a sudden, severe, and unexpected anaphylactoid reaction after an otherwise uncomplicated repair of a partial atrioventricular septal defect. The reaction, comprising haemorrhagic pulmonary oedema and peripheral circulatory collapse, followed neutralisation of heparin by protamine. Measurements of serum complement (C3 and C4) concentrations suggested that a pronounced consumption of complement occurred during the adverse response.

摘要

一名2岁半的男孩在进行了简单的部分房室间隔缺损修复术后,突然出现严重且意外的类过敏反应。该反应包括出血性肺水肿和外周循环衰竭,发生在鱼精蛋白中和肝素之后。血清补体(C3和C4)浓度的测量表明,在不良反应期间补体发生了显著消耗。

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本文引用的文献

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Cardiorespiratory effects of protamine after cardiopulmonary bypass in man.
Thorax. 1974 Sep;29(5):534-8. doi: 10.1136/thx.29.5.534.
10
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Acta Anaesthesiol Scand. 1977;21(4):293-307. doi: 10.1111/j.1399-6576.1977.tb01222.x.

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