Hughes V C, Cameron J, Goonetilleke A S
J Ment Defic Res. 1982 Jun;26 (Pt 2):115-20. doi: 10.1111/j.1365-2788.1982.tb00136.x.
A survey was made of the thyroid function of 402 mentally handicapped patients in a long-stay hospital and its satellite units. The prevalence of hypothyroidism in a 2-year period was 25/402 (6.2%), and 17/364 (4.7%) when people with Down's syndrome were excluded. Hyperthyroidism was found in 3/402 (0.7%). These results include 16 patients with hypothyroidism, and two with hyperthyroidism, who were newly detected during the surgery. With diagnosis, treatment was started. This occurrence of thyroid disorders is higher than in both the general population in the community and also in other psychiatric in-patients. Biochemical investigation is essential as the disorders are difficult to detect clinically, and untreated the patients are liable to the complications of hypothyroidism and hyperthyroidism.
对一家长期住院医院及其附属单位的402名智力障碍患者的甲状腺功能进行了调查。在两年期间，甲状腺功能减退症的患病率为25/402（6.2%），排除唐氏综合征患者后为17/364（4.7%）。甲状腺功能亢进症在402人中发现3例（0.7%）。这些结果包括16例甲状腺功能减退症患者和2例甲状腺功能亢进症患者，他们是在手术期间新发现的。确诊后即开始治疗。这些甲状腺疾病的发生率高于社区普通人群以及其他精神科住院患者。由于这些疾病在临床上难以检测，未经治疗的患者易患甲状腺功能减退症和甲状腺功能亢进症的并发症，因此生化检查至关重要。
