Goldman J N, Goldman M B
J Immunol. 1978 Feb;120(2):400-7.
We have shown that administration of anti-C5 antibody to newborn mice heterozygous for C5 deficiency can suppress C5 levels for prolonged periods. This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. Only certain sources of anti-C5 are effective in suppression. Of the three antisera extensively tested in (SWR x RIII)F1 hybrids, A/He anti-RIII was the most effective, SWR anti-RIII was less effective, and SWR anti-DBA/1 was ineffective. Only certain strain combinations of F1 hybrids are susceptible to C5 suppression. C5 suppression was seen with (SWR x RIII)F1 hybrids but not (SWR x DBA/1)F1 hybrids. Kinetics of C5 suppression suggest a requirement for an active, ongoing process in the maintenance of low C5 levels.
我们已经证明，给C5缺陷杂合的新生小鼠注射抗C5抗体能够长期抑制C5水平。这类似于抗体诱导的免疫球蛋白同种异型和独特型抑制。只有某些来源的抗C5在抑制方面有效。在（SWR×RIII）F1杂种中广泛测试的三种抗血清中，A/He抗RIII最有效，SWR抗RIII效果较差，而SWR抗DBA/1则无效。只有某些F1杂种的品系组合易受C5抑制。在（SWR×RIII）F1杂种中观察到了C5抑制，但在（SWR×DBA/1）F1杂种中未观察到。C5抑制的动力学表明，维持低C5水平需要一个活跃的、持续的过程。
