使用组织相容性无关志愿供者进行的严重再生障碍性贫血骨髓移植

Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors.

作者信息

Gordon-Smith E C, Fairhead S M, Chipping P M, Hows J, James D C, Dodi A, Batchelor J R

出版信息

Br Med J (Clin Res Ed). 1982 Sep 25;285(6345):835-7. doi: 10.1136/bmj.285.6345.835.

DOI:10.1136/bmj.285.6345.835

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1499685/

Abstract

Two patients with severe aplastic anaemia received bone-marrow transplants from unrelated donors selected for HLA compatibility. Graft-versus-host disease occurred in both patients but responded to treatment. Both patients had stormy courses after grafting, but subsequently their conditions improved, and one was not receiving any treatment at follow-up after day 330 while the other had mild chronic graft-versus-host disease at day 150. These results show that unrelated, histocompatible volunteers may successfully donate marrow for the treatment of severe aplastic anaemia, though many problems remain to be solved.

摘要

两名严重再生障碍性贫血患者接受了来自经HLA配型选择的无关供者的骨髓移植。两名患者均发生了移植物抗宿主病，但对治疗有反应。两名患者移植后病程均波折，但随后病情改善，一名患者在第330天后随访时未接受任何治疗，另一名患者在第150天时患有轻度慢性移植物抗宿主病。这些结果表明，无关的、组织相容性匹配的志愿者可为严重再生障碍性贫血的治疗成功捐献骨髓，尽管仍有许多问题有待解决。

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