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使用组织相容性无关志愿供者进行的严重再生障碍性贫血骨髓移植

Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors.

作者信息

Gordon-Smith E C, Fairhead S M, Chipping P M, Hows J, James D C, Dodi A, Batchelor J R

出版信息

Br Med J (Clin Res Ed). 1982 Sep 25;285(6345):835-7. doi: 10.1136/bmj.285.6345.835.

DOI:10.1136/bmj.285.6345.835
PMID:6214294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1499685/
Abstract

Two patients with severe aplastic anaemia received bone-marrow transplants from unrelated donors selected for HLA compatibility. Graft-versus-host disease occurred in both patients but responded to treatment. Both patients had stormy courses after grafting, but subsequently their conditions improved, and one was not receiving any treatment at follow-up after day 330 while the other had mild chronic graft-versus-host disease at day 150. These results show that unrelated, histocompatible volunteers may successfully donate marrow for the treatment of severe aplastic anaemia, though many problems remain to be solved.

摘要

两名严重再生障碍性贫血患者接受了来自经HLA配型选择的无关供者的骨髓移植。两名患者均发生了移植物抗宿主病，但对治疗有反应。两名患者移植后病程均波折，但随后病情改善，一名患者在第330天后随访时未接受任何治疗，另一名患者在第150天时患有轻度慢性移植物抗宿主病。这些结果表明，无关的、组织相容性匹配的志愿者可为严重再生障碍性贫血的治疗成功捐献骨髓，尽管仍有许多问题有待解决。

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本文引用的文献

1
Use of cyclosporin A in allogeneic bone marrow transplantation for severe aplastic anemia.环孢素A在严重再生障碍性贫血异基因骨髓移植中的应用。
Transplantation. 1982 Apr;33(4):382-6. doi: 10.1097/00007890-198204000-00008.
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Transplantation of marrow from an unrelated donor to a patient with acute leukemia.
N Engl J Med. 1980 Sep 4;303(10):565-7. doi: 10.1056/NEJM198009043031007.
3
Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.用抗淋巴细胞球蛋白或骨髓移植治疗严重再生障碍性贫血。
Br Med J (Clin Res Ed). 1981 Mar 14;282(6267):860-3. doi: 10.1136/bmj.282.6267.860.
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HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis.类风湿关节炎患者的HLA - DR抗原与金硫代苹果酸钠和青霉胺的毒性反应
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Severe aplastic anaemia: correlation of in vitro test with clinical response to immunosuppression in 20 patients.重型再生障碍性贫血：20例患者体外试验与免疫抑制临床反应的相关性
Br J Haematol. 1981 Mar;47(3):423-32. doi: 10.1111/j.1365-2141.1981.tb02810.x.
6
Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia.再生障碍性贫血或白血病骨髓移植后的水痘-带状疱疹病毒感染。
Transplantation. 1980;29(1):47-50. doi: 10.1097/00007890-198001000-00010.
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A semimicro mixed leukocyte culture test.半微量混合白细胞培养试验。
Transplantation. 1971 Mar;11(3):260-7. doi: 10.1097/00007890-197103000-00004.
8
Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HL-A-identifcal unrelated donor.使用表型HL-A匹配的无关供者对一名再生障碍性贫血患者进行异基因骨髓移植。
Transplantation. 1973 Jul;16(1):24-8. doi: 10.1097/00007890-197307000-00005.
9
Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality.
Blood. 1976 Jul;48(1):63-70.
10
Bone-marrow transplantation in severe aplastic anaemia.重型再生障碍性贫血的骨髓移植
Lancet. 1976 Oct 30;2(7992):921-3. doi: 10.1016/s0140-6736(76)90889-8.