Fleck W F, Schlegel B, Ihn W
Z Allg Mikrobiol. 1982;22(5):349-53. doi: 10.1002/jobm.3630220508.
The in vitro antimicrobial activity of iremycin (10-(alpha-L-rhodosaminyl)-gamma-rhodomycinone) was determined in comparison to that of doxorubicin, a 14-hydroxy-derivative of daunorubicin, which exhibited a strong antitumor activity and is useful in chemotherapy of human tumors. The MIC values determined by means of a standardized agar diffusion plate test indicated a lower antimicrobial activity of iremycin in vitro in comparison to that of doxorubicin. In contrast to doxorubicin, iremycin was highly active against Mycobacterium smegmatis, but five-fold less active than doxorubicin against Staphylococcus aureus, seven-fold less active against Bacillus subtilis, and twenty five-fold less active against Commamonas terrigena. Furthermore, iremycin was hundred-fold less active against a highly sensitive permeation mutant of Pseudomonas aeruginosa. No inducing activity on prophages in lysogenic E. coli cells was demonstrable for iremycin and no growth inhibition in the repair test was observable. In contrast, iremycin inhibited the multiplication of gamma-phages in the BIP test, but the MIC values of violamycin BI, doxorubicin and iremycin in this test system indicated that iremycin is two hundred fifty-fold less active than violamycin BI and ten-fold less active than doxorubicin. No serum binding was demonstrable for iremycin.
将伊雷霉素（10 -（α - L - 鼠李糖胺基）-γ - 红霉酮）的体外抗菌活性与阿霉素（柔红霉素的14 - 羟基衍生物）进行了比较，阿霉素具有很强的抗肿瘤活性，可用于人类肿瘤的化疗。通过标准化琼脂扩散平板试验测定的最低抑菌浓度（MIC）值表明，伊雷霉素的体外抗菌活性低于阿霉素。与阿霉素不同，伊雷霉素对耻垢分枝杆菌具有高活性，但对金黄色葡萄球菌的活性比阿霉素低五倍，对枯草芽孢杆菌的活性低七倍，对土生丛毛单胞菌的活性低二十五倍。此外，伊雷霉素对铜绿假单胞菌的高敏感渗透突变体的活性低一百倍。未证明伊雷霉素对溶原性大肠杆菌细胞中的原噬菌体有诱导活性，在修复试验中也未观察到生长抑制。相反，伊雷霉素在噬菌斑抑制试验（BIP试验）中抑制γ - 噬菌体的增殖，但该试验系统中紫霉素BI、阿霉素和伊雷霉素的MIC值表明，伊雷霉素的活性比紫霉素BI低二百五十倍，比阿霉素低十倍。未证明伊雷霉素有血清结合现象。
