Hoting E, Maurach R, Meigel W
Z Hautkr. 1982 Aug 1;57(15):1137-43.
Retinoids possess regulatory influences on growth and differentiation of epithelial tissues. They induce a population of keratinozytes with normal pattern of differentiation, they have antiproliferative properties, and they show antineoplastic effects by inhibition of malignant transformation of cells in vitro. Also the dermis undergoes distinct alterations under oral administration of retinoids. By stimulating T-lymphocytes and by inhibition of neutrophil migration retinoids seem to develop immunmodulating and antiinflammatory effects. The aromatic retinoid Etretinate is therapeutically used in severe forms of psoriasis and in various genodermatoses with disorders of keratinization as for example ichthyosis, dyskeratosis follicularis Darier, and pityriasis rubra pilaris.
维甲酸对上皮组织的生长和分化具有调节作用。它们可诱导一群具有正常分化模式的角质形成细胞，具有抗增殖特性，并通过抑制体外细胞的恶性转化显示出抗肿瘤作用。此外，口服维甲酸时真皮会发生明显改变。通过刺激T淋巴细胞和抑制中性粒细胞迁移，维甲酸似乎发挥免疫调节和抗炎作用。芳香维甲酸依曲替酯在严重银屑病及各种角化异常的遗传性皮肤病如鱼鳞病、毛囊角化病（达里埃病）和毛发红糠疹的治疗中应用。
