Pochi P E
Cutis. 1982 Aug;30(2):212-4, 216-7, 219 passim.
Acne is dependent for its development on several factors, one of which is hormonal. The principal and possibly sole mechanistic link between hormones and acne is sebum, the secretory product of the sebaceous glands which is highly androgen-sensitive. Some but not all, patients with acne can be shown to have systemic androgen abnormalities. In addition, there is evidence to suggest that androgens are metabolized abnormally in the skin, possibly resulting in excessive sebaceous gland secretion. Systemic endocrine therapy of acne is designed to reduce the androgenic stimulation of the sebaceous gland. Such treatment includes the peroral cyclic administration of estrogen for ovarian inhibition and the use of low-dosage glucocorticoid for adrenocortical androgen suppression. Combined estrogen-glucocorticoid treatment induces the most telling effect in reducing sebaceous gland activity.
痤疮的发生取决于多种因素，其中之一是激素。激素与痤疮之间主要且可能唯一的机制联系是皮脂，皮脂是皮脂腺的分泌产物，对雄激素高度敏感。部分而非全部痤疮患者可表现出全身性雄激素异常。此外，有证据表明雄激素在皮肤中代谢异常，这可能导致皮脂腺分泌过多。痤疮的全身性内分泌治疗旨在减少皮脂腺的雄激素刺激。此类治疗包括口服雌激素进行周期性给药以抑制卵巢功能，以及使用低剂量糖皮质激素抑制肾上腺皮质雄激素分泌。雌激素 - 糖皮质激素联合治疗在降低皮脂腺活性方面产生的效果最为显著。
