维甲酸乙酯和视黄酸对PHA和刀豆球蛋白A诱导的淋巴细胞转化、抑制细胞诱导及白细胞迁移抑制因子（LMIF）产生的体外差异效应。

Differential in vitro effects of etretinate and retinoic acid on the PHA and con A induced lymphocyte transformation, suppressor cell induction and leukocyte migration inhibitory factor (LMIF) production.

作者信息

Soppi E, Tertti R, Soppi A M, Toivanen A, Jansén C T

出版信息

Int J Immunopharmacol. 1982;4(5):437-43. doi: 10.1016/0192-0561(82)90018-2.

Abstract

The in vitro influence of two retinoids, etretinate and retinoic acid, on the human lymphocyte transformation, on the induction of suppressor cells and on leukocyte migration inhibitory factor (LMIF) production were investigated. Nontoxic concentration of retinoic acid increased significantly the PHA response to suboptimal mitogen concentrations, but had no effect on the Con A response; it also abolished the PHA induced LMIF production. In corresponding assays etretinate was without effect. Etretinate augmented the PHA induced suppressor cell activity, while retinoic acid was ineffective. No effect was observed on Con A induced suppressor cells by either retinoid. The findings extend the information about the immunomodulatory effects of retinoids and demonstrate that retinoic acid and etretinate have different effects on PHA and Con A induced immune responses. The mode of action of retinoids is discussed.

摘要

研究了两种维甲酸（依曲替酯和维甲酸）对人淋巴细胞转化、抑制细胞诱导及白细胞迁移抑制因子（LMIF）产生的体外影响。无毒浓度的维甲酸可显著增强对次优丝裂原浓度的PHA反应，但对Con A反应无影响；它还可消除PHA诱导的LMIF产生。在相应试验中，依曲替酯无此作用。依曲替酯可增强PHA诱导的抑制细胞活性，而维甲酸则无此作用。两种维甲酸对Con A诱导的抑制细胞均无影响。这些发现扩展了关于维甲酸免疫调节作用的信息，并表明维甲酸和依曲替酯对PHA和Con A诱导的免疫反应有不同影响。文中还讨论了维甲酸的作用方式。