Lei K Y
J Nutr. 1978 Feb;108(2):232-7. doi: 10.1093/jn/108.2.232.
The effect of copper deficiency on in vivo catabolism and excretion of [26-14C] cholesterol was studied in male rats. The study involved four treatments, namely, control, copper-deficient, control plus cholesterol, and copper-deficient plus cholesterol supplement. Significant elevations of serum ester and total cholesterol concentrations and reductions of serum free, ester, and total cholesterol specific activities were observed in rats fed the copper-deficient diets. In addition, a significant reduction of liver free cholesterol concentration was observed in rats fed the copper-deficient diets. Cholesterol supplementation significantly increased the concentrations of, and reduced the specific activities of, the different serum and liver cholesterol fractions. The only exception was that the liver free cholesterol concentration was not altered by cholesterol supplementation. The serum free cholesterol concentration was significantly increased and the specific activities of liver ester cholesterol were significantly reduced in rats fed the copper-deficient diet with no added cholesterol. The rates of oxidation and excretion of [26-14C] cholesterol were not influenced by dietary copper but were significantly increased by cholesterol supplementation. A shift of cholesterol from the liver to the serum pool appeared to be responsible for the hypercholesterolemia observed in copper deficiency.
在雄性大鼠中研究了铜缺乏对[26-¹⁴C]胆固醇体内分解代谢和排泄的影响。该研究包括四种处理，即对照、缺铜、对照加胆固醇以及缺铜加胆固醇补充剂。在喂食缺铜饮食的大鼠中，观察到血清酯和总胆固醇浓度显著升高，血清游离、酯和总胆固醇比活性降低。此外，在喂食缺铜饮食的大鼠中观察到肝脏游离胆固醇浓度显著降低。胆固醇补充显著增加了不同血清和肝脏胆固醇组分的浓度，并降低了其比活性。唯一的例外是胆固醇补充并未改变肝脏游离胆固醇浓度。在喂食无添加胆固醇的缺铜饮食的大鼠中，血清游离胆固醇浓度显著升高，肝脏酯胆固醇的比活性显著降低。[26-¹⁴C]胆固醇的氧化和排泄速率不受饮食铜的影响，但胆固醇补充使其显著增加。胆固醇从肝脏向血清池的转移似乎是铜缺乏时观察到的高胆固醇血症的原因。
