Jones E L, Craver J M, Grüntzig A R, King S B, Douglas J S, Bone D K, Guyton R G, Hatcher C R
Ann Thorac Surg. 1982 Nov;34(5):492-503. doi: 10.1016/s0003-4975(10)62994-3.
Over a recent one-year period, 339 patients underwent percutaneous transluminal coronary angioplasty (PTCA) and were compared with 338 patients having isolated coronary artery bypass surgery. Patients undergoing PTCA had a shorter duration of angina, a lower number of prior myocardial infarctions, and better left ventricular function (p less than 0.01); PTCA was considered initially successful in 87% (295/339) of patients. Repeat angioplasty was performed in 18% of patients (34/339), with a successful outcome in all but 1. The most common finding at operation in those with failed angioplasty and urgent or emergency revascularization was dissection of an atheromatous plaque. There were 28 early failures (operation performed within 24 hours) and 24 late failures (operation at more than 24 hours), for early and late failure rates of 8.3% and 7.1%, respectively. Although the cumulative frequency of new Q-waves in the entire angioplasty series was low (2.7%), the incidence was high in those with angioplasty failure and subsequent operation (18%), and was significantly greater than in patients having elective coronary bypass (3.6%). Use of inotropic agents and lidocaine treatment for ventricular arrhythmias was also significantly higher in patients with unsuccessful PTCA who required operation than in those undergoing elective bypass (10% versus 3% and 10% versus 1.5%, respectively; p less than 0.01). Eleven of the 28 patients who were early failures were totally revascularized within 2 hours of angioplasty failure. Facilities and staff available for expedient revascularization accounted for the low morbidity and lack of mortality in PTCA failures.
在最近一年期间,339例患者接受了经皮腔内冠状动脉成形术(PTCA),并与338例接受单纯冠状动脉搭桥手术的患者进行了比较。接受PTCA的患者心绞痛持续时间较短,既往心肌梗死次数较少,左心室功能较好(p<0.01);PTCA最初在87%(295/339)的患者中被认为成功。18%的患者(34/339)进行了重复血管成形术,除1例患者外均取得成功结果。血管成形术失败且需要紧急或急诊血运重建的患者术中最常见的发现是动脉粥样斑块夹层。有28例早期失败(在24小时内进行手术)和24例晚期失败(在24小时后进行手术),早期和晚期失败率分别为8.3%和7.1%。尽管在整个血管成形术系列中新Q波的累积发生率较低(2.7%),但在血管成形术失败并随后进行手术的患者中发生率较高(18%),且显著高于接受择期冠状动脉搭桥的患者(3.6%)。需要手术的PTCA不成功患者使用正性肌力药物和利多卡因治疗室性心律失常的比例也显著高于接受择期搭桥的患者(分别为10%对3%和10%对1.5%;p<0.01)。28例早期失败患者中有11例在血管成形术失败后2小时内实现了完全血运重建。可用于快速血运重建的设施和人员使得PTCA失败患者的发病率较低且无死亡病例。