Starek A, Kamiński M
Med Pr. 1982;33(1-3):1-14.
The rats exposed for 14 weeks to odourless kerosene mists (concentration of 75 and 300 mg/m3) had their urinary chemical and morphotic composition determined. In addition, morphological and cytoenzymatic examinations of kidneys were carried out. The findings were: increased pH and protein concentration and single erythrocytes in urine and also: passive congestion of renal cortex and medulla, infiltrates composed of granulocytes and eosinophils and albuminous casts in renal tubules. Decreased activity of succinate dehydrogenase, glucoso-6-phosphatase, Mg++ stimulated adenosinotriphosphatase and increased activity of acid phosphatase were found. Those changes were localized in cortical part of the kidney especially in the main tubules epithelial cells. The observed functional, morphological and cytoenzymatic changes depended on the magnitude of exposure. The obtained results confirm that kerosene hydrocarbons may exhibit toxic effects on the kidney function and structure.
将14周暴露于无味煤油雾（浓度为75和300毫克/立方米）中的大鼠的尿液化学和形态组成进行了测定。此外，还对肾脏进行了形态学和细胞酶学检查。结果发现：尿液pH值和蛋白质浓度升高，出现单个红细胞，同时还发现：肾皮质和髓质被动性充血，由粒细胞和嗜酸性粒细胞组成的浸润以及肾小管中的白蛋白管型。琥珀酸脱氢酶、葡萄糖-6-磷酸酶、镁离子刺激的三磷酸腺苷酶活性降低，酸性磷酸酶活性升高。这些变化主要发生在肾脏皮质部分，尤其是主肾小管上皮细胞。观察到的功能、形态和细胞酶学变化取决于暴露程度。所得结果证实煤油碳氢化合物可能对肾脏功能和结构产生毒性作用。
