Kruger M, Booyens J
S Afr Med J. 1982 Nov 27;62(23):855-8.
The effects of the prostaglandin derivative PGBx on calcium release and uptake by skeletal muscle sarcoplasmic reticulum (SR) and on (Ca2+ + Mg2+)- adenosine triphosphatase (ATPase) activity were studied using skeletal muscle from rabbit hind legs. Both calcium uptake and Ca2+-ATPase activity were significantly inhibited by PGBx. Addition of PGBx to SR vesicles resulted in the release of calcium. It is proposed that this action of PGBx could be effected by the inhibition of ATPase and resulting passive release of calcium. The possibility also exists that PGBx could decrease the capacity of the SR vesicles for calcium in addition to any possible ionophoretic properties.
利用兔后腿骨骼肌研究了前列腺素衍生物PGBx对骨骼肌肌浆网（SR）钙释放和摄取以及对（Ca2+ + Mg2+）-三磷酸腺苷酶（ATPase）活性的影响。PGBx显著抑制了钙摄取和Ca2+-ATPase活性。向SR囊泡中添加PGBx导致钙释放。有人提出，PGBx的这种作用可能是通过抑制ATPase以及由此导致的钙被动释放来实现的。除了任何可能的离子载体特性外，PGBx还可能降低SR囊泡对钙的容纳能力，这种可能性也存在。
