Heinonen P K, Metsä-Ketelä T, Tuohimaa P
J Reprod Fertil. 1978 Jan;52(1):159-62. doi: 10.1530/jrf.0.0520159.
In immature, diethylstilboestrol-treated chicks, ligation of the oviduct caused local avidin synthesis in the immediate vicinity of the ligature. PGF-2alpha injected directly into the oviduct also induced avidin synthesis, whereas saline or PGE-2 had no effect. PGE and PGF-2alpha concentrations increased in the oviduct within 24 h of ligation: the PGE increase could be partly inhibited by indomethacin, whereas that of PGF-2alpha was less inhibited. An LD50 dose of indomethacin alone and with ligation had a clear stimulatory effect on avidin synthesis, whereas aspirin alone, or with ligation, was not effective. Ligation alone and with indomethacin appeared to alter the PGF-2alpha/PGE ratio. These results suggest that PGF-2alpha may be involved in the regulation of avidin synthesis in the chick oviduct.
在未成熟的、经己烯雌酚处理的雏鸡中，输卵管结扎导致结扎部位附近局部抗生物素蛋白合成。直接注入输卵管的前列腺素F2α也诱导抗生物素蛋白合成，而生理盐水或前列腺素E2则无此作用。结扎后24小时内，输卵管中前列腺素E和前列腺素F2α浓度升高：吲哚美辛可部分抑制前列腺素E的升高，而对前列腺素F2α升高的抑制作用较小。单独使用吲哚美辛的半数致死剂量以及与结扎联合使用时，对抗生物素蛋白合成有明显的刺激作用，而单独使用阿司匹林或与结扎联合使用则无效。单独结扎以及与吲哚美辛联合使用似乎会改变前列腺素F2α/前列腺素E的比例。这些结果表明，前列腺素F2α可能参与雏鸡输卵管中抗生物素蛋白合成的调节。
