Köhnlein W, Jung G
Arzneimittelforschung. 1982;32(11):1474-9.
This article describes the properties and biological actions of the antitumor protein neocarzinostatin which stands for a whole group of high molecular weight antitumor antibiotics. Special emphasis is given to the development of our understanding of the molecular mechanism of neocarzinostatin action. From this mechanism of action far-reaching perspectives concerning the clinical application of neocarzinostatin are discussed.
本文描述了抗肿瘤蛋白新制癌菌素的特性和生物学作用,新制癌菌素代表了一整类高分子量抗肿瘤抗生素。特别强调了我们对新制癌菌素作用分子机制认识的发展过程。基于这种作用机制,讨论了新制癌菌素临床应用的深远前景。