Gupta S
Immunol Lett. 1982 Aug;5(2):101-5. doi: 10.1016/0165-2478(82)90041-4.
Autologous mixed lymphocyte reaction (AMLR) between T and non-T cells was studied in 12 patients with selective IgA deficiency. Seven of 12 patients demonstrated significantly (P less than 0.05) lower AMLR when compared to simultaneously studied age and sex matched controls. In the allogeneic MLR, T cells from patients responded normally to control non-T cells; however, non-T cells from patients were poor stimulators against normal responder T cells when compared to allogeneic MLR between different normal controls. The deficient AMLR in selective IgA deficiency further supports abnormal immune regulation and might explain the increased incidence of autoimmune phenomena and autoimmune diseases associated with selective IgA deficiency.
对12例选择性IgA缺乏症患者的T细胞与非T细胞之间的自体混合淋巴细胞反应（AMLR）进行了研究。与同时研究的年龄和性别匹配的对照组相比，12例患者中有7例表现出显著更低的AMLR（P<0.05）。在同种异体混合淋巴细胞反应（MLR）中，患者的T细胞对对照非T细胞反应正常；然而，与不同正常对照之间的同种异体MLR相比，患者的非T细胞对正常反应性T细胞的刺激作用较差。选择性IgA缺乏症中AMLR的缺陷进一步支持了免疫调节异常，并可能解释了与选择性IgA缺乏症相关的自身免疫现象和自身免疫性疾病发病率增加的原因。
