The treatment of surgical infections by deep intramuscular administration of mezlocillin.

Thirty adult inpatients were enrolled in an open multicenter study to determine the efficacy and tolerability of mezlocillin injected i.m. in surgical bacterial infections. Clinical, bacteriological and laboratory controls were performed. The infections were caused by gram-negative and/or gram-positive bacteria. Twenty-seven patients were cured bacteriologically and clinically. One patient had a relapse and there was a failure in two. The local and systemic tolerance was very good. One patient experienced nausea, headache and intestinal pain on the second day of treatment. These symptoms subsided spontaneously shortly after mezlocillin treatment was discontinued.