Youinou P, Miossec P
Nouv Presse Med. 1982 Nov 20;11(47):3501-4.
When primary and not part of a systemic autoimmune disease, Sjögren's syndrome has peculiar clinical, serological and genetic features. It exceptionally becomes malignant but evolves to a stage of pseudo-lymphoma. Numerous studies suggest hyperstimulation of B-lymphocytes that would result from destruction of suppressive T-lymphocytes, this destruction in turn being probably due to failure of immune complex clearing by the reticulo-endothelial system.
当原发性干燥综合征并非全身性自身免疫性疾病的一部分时，具有独特的临床、血清学和遗传学特征。它极少恶变，但会发展为假性淋巴瘤阶段。众多研究表明，抑制性T淋巴细胞的破坏会导致B淋巴细胞过度刺激，而这种破坏反过来可能是由于网状内皮系统清除免疫复合物失败所致。
