小鼠髓系白血病细胞分化过程中染色体高迁移率族蛋白HMG1和HMG2的保守性
Conservation of chromosomal high mobility group proteins HMG1 and HMG2 during differentiation of mouse myeloid leukemia cells.
作者信息
Iketani K, Sakagami H, Nakaya K, Konno K
出版信息
Gan. 1982 Dec;73(6):902-6.
PMID:6219031
Abstract
The possible change in the levels of high mobility group proteins HMG1, HMG2 and histone H1 and H1(0) was investigated during mouse myeloid leukemia (M1) cell differentiation. In contrast to Friend erythroleukemia cells, no change occurred in the levels of any of these proteins. However, histone H1 phosphorylation significantly decreased. The results suggest that the loss of HMG1 and HMG2 proteins is not a generalized marker for cell differentiation.
摘要
在小鼠髓系白血病（M1）细胞分化过程中，研究了高迁移率族蛋白HMG1、HMG2以及组蛋白H1和H1(0)水平的可能变化。与弗氏红白血病细胞不同，这些蛋白的水平均未发生变化。然而，组蛋白H1磷酸化显著降低。结果表明，HMG1和HMG2蛋白的缺失并非细胞分化的普遍标志物。
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