Rybczyńska M, Chmiel J
Pol J Pharmacol Pharm. 1982;34(1-3):177-82.
We investigated the action of radioprotective agents: sodium S-(4-ethylphenylcarbonylmethylene)-thiosulfuric acid (SEPT), 2-(4-chlorophenyl)-thiazolidine (CPT) and dimethylsulfoxide (DMSO), on Na+/K+ATPase and Mg2+ATPase activity. SEPT inactivated more strongly Mg2+ATPase than Na+/K+ATPase, CPT dissolved in DMSO inhibited the activity of Mg2+ATPase, but did not affect that of Na+/K+ATPase. DMSO alone increased the activity of Mg2+ATPase and inhibited that of Na+/K+ATPase. Thus DMSO and CPT seem to act antagonistically on the activity of ATPases. The results indicate that radioprotectants strongly affect ATPases participating in membrane transport.
S-(4-乙基苯基羰基亚甲基)-硫代硫酸钠盐（SEPT）、2-(4-氯苯基)-噻唑烷（CPT）和二甲基亚砜（DMSO）对Na+/K+ATP酶和Mg2+ATP酶活性的作用。SEPT对Mg2+ATP酶的失活作用比对Na+/K+ATP酶更强，溶解于DMSO中的CPT抑制Mg2+ATP酶的活性，但不影响Na+/K+ATP酶的活性。单独的DMSO增加Mg2+ATP酶的活性并抑制Na+/K+ATP酶的活性。因此，DMSO和CPT似乎对ATP酶的活性起拮抗作用。结果表明，辐射防护剂强烈影响参与膜转运的ATP酶。
