Delorme P
Presse Med. 1983 Mar 24;12(13):830-8.
The effects of ischaemia on nervous tissue and cerebral capillary vessel ultrastructure and their prevention by Duxil were studied in rabbits. Ischaemia induced by bilateral occlusion of the carotid arteries induced minor changes in the endothelium of some capillary vessels: irregularities in the luminal surface with subsequent increase in the number of caveolae, increase in the number and size of membrane microvillosities and bullae, and retraction of the nuclei. Ischaemia acted mainly on astrocyte processes and perikarion which became shollen with altered mitochondria and complete absence of glycogen. The neurons remained normal but seemed to contain slightly more lysosomes. After administration of Duxil 10 min before ischaemia was induced, there were no endothelial changes; the astrocytes were less swollen and above all, their glycogen content was preserved; there seemed to be less lysosomes in the neurons. The effects of Duxil on cell oxygenation and oxidative metabolism may account for its protective action on endothelial, glial and neural cells.
在兔身上研究了缺血对神经组织和脑毛细血管超微结构的影响以及都可喜对其的预防作用。双侧颈总动脉闭塞诱导的缺血导致一些毛细血管内皮出现轻微变化：管腔表面不规则，随后小窝数量增加，膜微绒毛和大泡的数量及大小增加，细胞核回缩。缺血主要作用于星形胶质细胞的突起和核周体，使其肿胀，线粒体改变，糖原完全缺失。神经元保持正常，但似乎含有稍多的溶酶体。在诱导缺血前10分钟给予都可喜后，未出现内皮变化；星形胶质细胞肿胀减轻，最重要的是，其糖原含量得以保留；神经元中的溶酶体似乎减少。都可喜对细胞氧合和氧化代谢的作用可能解释了其对内皮细胞、神经胶质细胞和神经细胞的保护作用。
