Le Menn R
C R Seances Soc Biol Fil. 1982;176(5):650-5.
Flurbiprofene or acetylsalicylic acid did not change the structure of inactivated platelets. With flurbiprofene 50% aggregation inhibition was obtained at 10(-6) to 10(-5) M concentrations. To obtain the same result with acetylsalicylic acid, 10(-4) to 10(-3) M concentrations were necessary. With both agents, shape change was inhibited. The platelets in the small aggregates did not have the normal stretched dumb-bell shape but remained globulous and emitted a broad pseudopode containing normally-repolymerized microtubules.
氟比洛芬或乙酰水杨酸不会改变失活血小板的结构。对于氟比洛芬，在浓度为10⁻⁶至10⁻⁵ M时可获得50%的聚集抑制率。要用乙酰水杨酸获得相同结果，则需要10⁻⁴至10⁻³ M的浓度。两种药物均能抑制形状改变。小聚集体中的血小板没有正常的伸展哑铃状，而是保持球状，并伸出一个包含正常再聚合微管的宽伪足。
