Bousquet J, Fizet D, Grobon F, Dubecq J P
C R Seances Soc Biol Fil. 1982;176(5):656-62.
12 women with recurrent abortions are investigated for various immunological parameters. Couples studied shared several HLA antigens, those women do not develop HLA' antibodies and cellular cytotoxicity against their husband. Their serum has an abnormal glycoprotein, migrating in the alpha globulin zone, precipitating with anti beta globulin serum. The women studied with recurrent abortions never possessed the Blocking Factor present in the serum of pregnant women, able to inhibit a cellular cytotoxicity reaction in vitro. It is proposed a reliable and simple test which could inform on the outcome of abortions.
对12名复发性流产的女性进行了多种免疫学参数的研究。所研究的夫妇有几种共同的HLA抗原，这些女性不会产生针对其丈夫的HLA抗体和细胞毒性。她们的血清有一种异常糖蛋白，在α球蛋白区迁移，能与抗β球蛋白血清沉淀。研究的复发性流产女性从未拥有过孕妇血清中存在的阻断因子，该因子能够在体外抑制细胞毒性反应。提出了一种可靠且简单的检测方法，可告知流产的结果。
