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[下丘脑前部损伤对家鸽血浆甲状腺素和皮质酮昼夜变化的影响]

[Repercussions of anterior hypothalamic lesions on nycthemeral variations of plasma thyroxine and corticosterone in the pigeon].

作者信息

Ami M, Herbuté S, Ramade F, Bouillé C, Baylé J D

出版信息

C R Seances Soc Biol Fil. 1982;176(5):670-4.

PMID:6220770
Abstract

Plasma thyroxine and corticosterone levels were determined by competitive protein binding assay, at 3 hr intervals, throughout the photoperiod. Pigeons were kept in controlled environment (21 +/- 1 degree C; 14L6-20: 10D). Intact controls exhibited low thyroxine (T4) and corticosterone (B) levels for the light phase of the photoperiod. Values were rising during the night, up to a peak at 03 hr. Electrolytic lesions were placed bilaterally in either the nucleus anterior medialis hypothalami or the n. preopticus, or the n. supraopticus. Circadian rhythms of both T4 and B were markedly altered in all lesioned pigeons, with a shift of very high T4 values to the morning times and a complete disorganization of B patterns, with very heterogeneous values. The possibility is raised that anterior hypothalamic formations participate in the endogenous oscillator circuitry in birds.

摘要

在整个光照周期内,每隔3小时通过竞争性蛋白结合分析法测定血浆甲状腺素和皮质酮水平。鸽子饲养在可控环境中(21±1摄氏度;14L6-20:10D)。完整对照组在光照周期的光照阶段甲状腺素(T4)和皮质酮(B)水平较低。数值在夜间上升,在03时达到峰值。双侧电解损伤下丘脑前内侧核、视前核或视上核。所有损伤鸽子的T4和B的昼夜节律均明显改变,T4的极高值转移到早晨,B模式完全紊乱,数值非常不均一。这就提出了下丘脑前部结构参与鸟类内源性振荡器电路的可能性。

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