Najean Y, Vigneron N, Eberlin A, Dresch C, Delons S, Naret C, Petrover M, Aubert P
Presse Med. 1983 Apr 16;12(17):1063-6.
Fifty-two patients with anaemia due to chronic renal insufficiency treated by haemodialysis were divided into three severity groups. Except for bi-nephrectomized patients, none of the usual criteria such as age, sex, cause of the renal disease and duration of dialysis correlated with clinical severity. Kinetic studies showed that the severity of anaemia was unrelated to the degree of haemolysis, haemoglobin function or haemodilution. Stem cells were increased in all cases, irrespective of clinical severity. However, the degree of anaemia closely correlated with the degree of erythropoietic deficiency, as measured by radio-iron kinetics. A qualitative defect (slow release of labelled cells from the bone marrow) was associated with severe quantitative erythroid defect. These data indicate that kinetic studies of erythropoiesis constitute objective methods for measuring clinical severity. They favour the theory which makes a hypothetical inhibitor of differentiation and/or proliferation of erythropoietic precursors the main cause of anaemia.
52例因慢性肾功能不全接受血液透析治疗的贫血患者被分为三个严重程度组。除双侧肾切除患者外，年龄、性别、肾病病因和透析时间等常见标准均与临床严重程度无关。动力学研究表明，贫血的严重程度与溶血程度、血红蛋白功能或血液稀释程度无关。无论临床严重程度如何，所有病例中的干细胞均增加。然而，贫血程度与通过放射性铁动力学测量的红细胞生成不足程度密切相关。定性缺陷（标记细胞从骨髓中缓慢释放）与严重的定量红细胞系缺陷相关。这些数据表明，红细胞生成的动力学研究构成了测量临床严重程度的客观方法。它们支持将红细胞生成前体分化和/或增殖的假设抑制剂作为贫血主要原因的理论。
