晚期前列腺癌：用促性腺激素释放激素激动剂治疗
Advanced carcinoma of the prostate: treatment with a gonadotrophin releasing hormone agonist.
作者信息
Allen J M, O'Shea J P, Mashiter K, Williams G, Bloom S R
出版信息
Br Med J (Clin Res Ed). 1983 May 21;286(6378):1607-9. doi: 10.1136/bmj.286.6378.1607.
Abstract
Ten patients with advanced progressive adenocarcinoma of the prostate were treated with a long acting analogue of gonadotrophin releasing hormone. Eight of these patients responded to treatment in terms of pain relief and clinical regression of tumour. Serum gonadotrophin and testosterone concentrations were significantly suppressed by the end of the second week of treatment, testosterone concentrations being comparable with those achieved by castration. The two patients who failed to respond had both relapsed previously when receiving conventional treatment, and neither showed any endocrine response to the analogue. Superagonists of gonadotrophin releasing hormone may be the treatment of choice in adenocarcinoma of the prostate, but further trials are required to establish long term safety and efficacy.
摘要
十名晚期进展性前列腺腺癌患者接受了促性腺激素释放激素长效类似物治疗。其中八名患者在疼痛缓解和肿瘤临床消退方面对治疗有反应。治疗第二周结束时，血清促性腺激素和睾酮浓度被显著抑制，睾酮浓度与去势所达到的浓度相当。两名无反应的患者在接受传统治疗时均曾复发，且对该类似物均未表现出任何内分泌反应。促性腺激素释放激素超级激动剂可能是前列腺腺癌的首选治疗方法，但需要进一步试验以确定其长期安全性和疗效。
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本文引用的文献
1
Management of prostate carcinoma.
N Y State J Med. 1981 Sep;81(10):1481-5.
2
Incidence and etiology of prostate cancer.
Urology. 1981 Mar;17(Suppl 3):4-10.
3
Hormone therapy in prostatic cancer.
Acta Urol Belg. 1980 Jan;48(1):98-105.
4
Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists.
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1658-62. doi: 10.1073/pnas.79.5.1658.
5
Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men: an approach toward the development of a male contraceptive.
N Engl J Med. 1981 Sep 17;305(12):663-7. doi: 10.1056/NEJM198109173051203.
6
Sustained suppression of testosterone production by the luteinising-hormone releasing-hormone agonist buserelin in patients with advanced prostate carcinoma. A new therapeutic approach?
Lancet. 1982 May 15;1(8281):1097-9. doi: 10.1016/s0140-6736(82)92279-6.
7
Clomiphene citrate in men: increase of cortisol, luteinizing hormone, testosterone and steroid-binding globulins.
J Endocrinol. 1972 May;53(2):261-76. doi: 10.1677/joe.0.0530261.
8
Pulsatile patterns of gonadotropin release in subjects with and without ovarian function.
J Clin Endocrinol Metab. 1972 Apr;34(4):671-5. doi: 10.1210/jcem-34-4-671.
9
Human luteinizing hormone in man: studies of metabolism and biological action.
J Endocrinol. 1973 Mar;56(3):431-9. doi: 10.1677/joe.0.0560431.
10
Serum testosterone and dihydrotestosterone changes with age in rat.
Steroids. 1975 Jun;25(6):753-62. doi: 10.1016/0039-128x(75)90039-2.
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